A recent study by Hughes et al. [1] showed that cysteine-mediated iron deficiency is the main cause of aging-related mitochondrial dysfunction. They also uncovered that aging-induced vacuolar/lysosomal de-acidification participates in the cysteine-mediated iron deficiency, implying that the de-acidifying lysosome triggers vacuolar/lysosomal dysfunction and iron deficiency, further leading to mitochondrial dysfunction. Previous studies showed that iron and lysosomal-mitochondrial crosstalk are the two important mechanisms that lysosome regulates aging, and it is well known that iron plays a piv...
