The immune system plays a vital role in restoring tissue integrity and function upon injury. Wound healing is a highly dynamic process that involves early inflammatory phase, proliferative phase, and finally the maturation phase. Tissue repair begins with the formation of granulation tissue that contains macrophages to play anti-inflammatory roles. Macrophages within the granulation tissue acquire a spectrum of phase-specific phenotypes affecting fibroblast function, including myofibroblast differentiation, myofibroblast proliferation, and extracellular matrix(ECM) remodeling [1]. Nevertheless...
