MCU deficiency blocks cell proliferation by disrupting cytoplasmic Ca~(2+) transients due to altered Drp1 hospitalization

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成果类型：

期刊论文

作者：

Li Wang;Kai Zhang;Nian Fu;Lanfang Li

通讯作者：

Nian Fu<&wdkj&>Lanfang Li

作者机构：

[Kai Zhang; Lanfang Li] Institute of Pharmacy and Pharmacology , Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China

[Nian Fu] Department of Gastroenterology , Affiliated Nanhua Hospital, University of South China, Hengyang Hunan, China

[Li Wang] Institute of Pharmacy and Pharmacology , Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China<&wdkj&>Department of Gastroenterology , Affiliated Nanhua Hospital, University of South China, Hengyang Hunan, China

通讯机构：

[Nian Fu] D

[Lanfang Li] I

Institute of Pharmacy and Pharmacology , Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China<&wdkj&>Department of Gastroenterology , Affiliated Nanhua Hospital, University of South China, Hengyang Hunan, China

语种：

英文

关键词：

cell proliferation;cytoplasm;mitochondria

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2020

卷：

期：

页码：

215-217

DOI：

10.1093/abbs/gmz143

基金类别：

This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81670265 and 81970431), and the Innovation Platform Open Foundation of Education Department of Hunan Province (No. 18K073).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Mitochondrial calcium uniporter (MCU) is a highly selective Ca~(2+) channel protein of the mitochondria inner membrane [1], which allows divalent cations (Ca~(2+) ≈Sr~(2+) >>Mn~(2+) ≈Ba~(2+)) to permeate [2]. The MCU is a 40-kDa protein that contains a proteolytically cleaved mitochondrial import sequence, two coiled-coil domains, two transmembrane domains, and a short motif of amino acids between the two transmembrane domains critical for Ca~(2+) transport [3]. MCU is widely expressed in the mitochondrial inner membrane of various cells [4]....

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MCU deficiency blocks cell proliferation by disrupting cytoplasmic Ca~(2+) transients due to altered Drp1 hospitalization

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