Interleukin-5 promotes ATP-binding cassette transporter A1 expression through miR-211/JAK2/STAT3 pathways in THP-1-dervied macrophages

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成果类型：

期刊论文

作者：

Chen, Kong;Zhao, Zhenwang;Wang, Gang;Zou, Jin;Yu, Xiaohua;...

通讯作者：

Zeng, Gaofeng;Tang, Chaoke

作者机构：

[Zhao, Zhenwang; Tang, Chaoke; Zeng, Gaofeng; Chen, Kong; Wang, Gang; Zou, Jin] Univ South China, Key Lab Atherosclerol Hunan Prov, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch,Dept Cardiol,Affiliated Hosp 2,I, Hengyang 421001, Peoples R China.

[Wang, Gang; Zou, Jin] Univ South China, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Peoples R China.

[Yu, Xiaohua] Hainan Med Univ, Affiliated Hosp 2, Inst Clin Med, Haikou 460106, Hainan, Peoples R China.

[Zhang, Dawei] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada.

[Zhang, Dawei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada.

通讯机构：

[Zeng, GF; Tang, CK] U

Univ South China, Key Lab Atherosclerol Hunan Prov, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch,Dept Cardiol,Affiliated Hosp 2,I, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

IL-5;miR-211;JAK2/STAT3 pathway;ABCA1;cholesterol efflux

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2020

卷：

期：

页码：

832-841

DOI：

10.1093/abbs/gmaa071

基金类别：

The work was supported by the grants from the National Natural Sciences Foundation of China (No. 81770461), the Natural Science Foundation of Hunan Province (No. 2017JJ2224), and Hunan Province Health and Family Planning Scientific Research Project (No. B2019108).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Interleukin-5 (IL-5) is manifested as its involvement in the process of atherosclerosis, but the mechanism is still unknown. In this study, we explored the effect of IL-5 on lipid metabolism and its underlying mechanisms in THP-1-derived macrophages. The quantitative polymerase chain reaction (qPCR) and western blot analysis results showed that IL-5 significantly up-regulated ATP-binding cassette transporter A1 (ABCA1) expression in a dose-dependent and time-dependent manner. [3H]-labeled cholesterol was used to assess the levels of cholesterol efflux, and the results showed that IL-5 increase...

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Interleukin-5 promotes ATP-binding cassette transporter A1 expression through miR-211/JAK2/STAT3 pathways in THP-1-dervied macrophages

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