PRMT2β suppresses autophagy and glycolysis pathway in human breast cancer MCF-7 cell lines

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成果类型：

期刊论文

作者：

Yajun Chenx;Xianpeng Dai;Yao Yao;Jing Wang;Xinzhi Yang;...

通讯作者：

Gebo Wen<&wdkj&>Jing Zhong

作者机构：

[Yao Yao; Zhong J.; Yang X.; Wang J.] Institute of Clinical Medicine, First Affiliated Hospital of University of South China, Hengyang, 421001, China

Department of Metabolism and Endocrinology, Second Affiliated Hospital of University of South China, Hengyang, 421001, China

[Dai X.] Department of General Surgery, Second Affiliated Hospital of University of South China, Hengyang, 421001, China

[Zhang Y.] Institute of Clinical Medicine, Second Affiliated Hospital of University of South China, Hengyang, 421001, China

Department of Metabolism and Endocrinology, First Affiliated Hospital of University of South China, Hengyang, 421001, China

通讯机构：

[Gebo Wen; Jing Zhong] I

Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, China<&wdkj&>Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, China<&wdkj&>Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, China

语种：

英文

关键词：

MCF-7;apoptosis;expression;treatment;CYCLIN;can;Akt;its

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2019

卷：

期：

页码：

335-337

DOI：

10.1093/abbs/gmz006

基金类别：

This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81773294, 81472608 and 31200573), the Project of Education Department of Hunan Province (Nos. 16A189 and 15C1204), the Natural Science Foundation of Hunan Province (No. 13JJ6051) and the Chuanshan Talent Project of the University of South China (No. CS2018-3-35).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Autophagy as a novel therapeutic target can inhibit or increase treatment efficacy in various types of breast cancer in a cell-type-dependent manner [1,2].Several studies have revealed that the coordination between Akt and the glycolytic pathway plays an indispensable role in mediating autophagy and caspase-dependent apoptosis,suggesting that a new regulatory mechanism for the process [3,4].Protein arginine N-methyltransferases(PRMTs)are eukaryotic enzymes that catalyze the transfer of methyl groups from S-adenosylmethionine to arginine residue...

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PRMT2β suppresses autophagy and glycolysis pathway in human breast cancer MCF-7 cell lines

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