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The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation.

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成果类型:
期刊论文
作者:
Yiyuan Yang;Kai Zhang;Linxi Chen;Lanfang Li
通讯作者:
Linxi Chen<&wdkj&>Lanfang Li
作者机构:
[Yiyuan Yang; Lanfang Li; Kai Zhang; Linxi Chen] Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China
通讯机构:
[Linxi Chen; Lanfang Li] I
Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China
语种:
英文
关键词:
INDUCING;ADULT;CARDIOMYOCYTE;proliferation;myocardial;infarction(MI);regeneration;capacity
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2019
卷:
51
期:
4
页码:
452-454
基金类别:
This work was supported by the grants from the National Natural Science Foundation of China (No. 81670265) and Hunan Provincial Natural Science Foundation (No. 2017JJ2227).
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Cardiomyocytes, also known as myocardial fibers, are the muscle cells which form the heart tissue. Previous studies have indicated that fetal mammalian cardiomyocytes maintain the regeneration capacity, which promotes the fetal heart growth. Regardless of environment insults including nutrient deprivation, changes of blood flow, along with mechanical and volume loading [1], embryonic mammalian cardiac muscle cells are also related to robust proliferation response. Similarly, the hearts of 1-day-old neonatal mice could also be fully regenerated after surgical resection of the left ventricular a...
摘要(中文):
[无可用...

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