期刊论文

Feng, S.

英文

生物化学与生物物理学报

1672-9145

2018

50

3

298-306

10.1093/abbs/gmy003

We would like to express our heartfelt gratitude to Prof. Xilong Zheng （Department of Biochemistry and Molecular Biology, Health Sciences Center, the Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada） and Dr Shi Zhe （Hunan University of Chinese Medicine, Changsha, China）, who helped edit the article and also offered us valuable suggestions and comments.

本校为第一机构

Type 2 diabetes mellitus (T2DM) leads to cognitive impairment (CI), but there have been no effective pharmacotherapies or drugs for cognitive dysfunction in T2DM. Dihydromyricetin (DHM) is a natural flavonoid compound extracted from the leaves of Ampelopsis grossedentata and has various pharmacological effects including anti-oxidant and anti-diabetes. Thus, we investigated the effects of DHM on CI in T2DM mouse model and its possible mechanism. To induce T2DM, mice were fed with high-sugar and high-fat diet for 8 weeks, followed by a low dose streptozotocin (STZ) administration. After the succ...

类型 2 糖尿病 mellitus (T2DM ) 导致认知缺陷(CI ) ，但是为在 T2DM 的认知机能障碍没有有效 pharmacotherapies 或药。Dihydromyricetin (DHM ) 是从白蔹属 grossedentata 的叶子提取的自然 flavonoid 混合物并且包括抗氧化剂和反糖尿病有各种各样的药理学效果。因此，我们在 T2DM 老鼠模型和它的可能的机制在 CI 上调查了 DHM 的效果。导致 T2DM，老鼠用高糖、高脂肪的饮食被喂 8 个星期，由低剂量 streptozotocin (STZ ) 列在后面管理。在 T2DM 鼠标模型的成功的正式就职以后，鼠标与相等的体积分别地被对待盐(T2DM 组) ， 125 mg/kg/d DHM (L-DHM 组) ，或 250 mg/kg/d DHM (H-DHM 组) 。...