HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Xinyun;Lv, Yuan;He, Panpan;Wang, Zongbao;Xiong, Fang;...

通讯作者：

Tang, Chaoke;Cao, Qi

作者机构：

[Wang, Zongbao; Tang, Chaoke; He, Linhao; Xiong, Fang; Huang, Xinyun; Lv, Yuan] Med Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Cao, Qi; Huang, Xinyun] Univ South China, Affiliated Hosp 2, Dept Spine Surg, Hengyang 421001, Peoples R China.

[He, Panpan; Wang, Zongbao; He, Linhao; Xiong, Fang; Lv, Yuan] Univ South China, Sch Pharm & Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Zheng, Xilong] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol,Cumming Sch Med, Calgary, AB T2N 4N1, Canada.

[Zheng, Xilong] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Physiol & Pharmacol,Cumming Sch Med, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chaoke] M

[Cao, Qi] U

Med Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Spine Surg, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

HDL;ABCG1;cholesterol efflux;osteoclastogenesis;osteoclast apoptosis

关键词(中文)：

损害;胆固醇;主要部件;酒石酸盐;时间依赖;调查结果

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2018

卷：

期：

页码：

853-861

DOI：

10.1093/abbs/gmy081

基金类别：

This work was supported by a grant from the National Natural Sciences Foundation of China (No. 81570408).

机构署名：

本校为通讯机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Cholesterol is one of the major components of biological membranes and has an important function in osteoclast formation and survival. It has been reported that high-density lipoprotein (HDL) promotes cholesterol efflux from osteoclasts and induces their apoptosis, but the underlying mechanisms are unclear. In this study, we investigated how HDL promotes osteoclast cholesterol efflux and explored its effect on osteoclast formation and survival. Our results showed that the maximum diameter and fusion index of osteoclasts were decreased, while th...

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HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression

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