Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Zhang, Xin;Ye, Qiong;Gong, Duo;Lv, Yuan;Cheng, Haipeng;...

通讯作者：

Wang, Zongbao;Tang, Chaoke

作者机构：

[Zhang, Xin; Gong, Duo; Zhao, Zhenwang; Wei, Xie; Wang, Zongbao; Chen, Lingyan; Ye, Qiong; Tang, Chaoke; Cheng, Haipeng; Zhang, Min; Yu, Xiaohua; Wang, ZB; Tang, CK; Li, Liang; Xia, Xiaodan; Lv, Yuan; Huang, Chong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Med Res Ctr, Hengyang 421001, Peoples R China.

[Zhang, Xin; Wang, Zongbao; Lv, Yuan; Wang, Shuzhi] Univ South China, Sch Pharm & Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Ye, Qiong] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Peoples R China.

[Zheng, Xilong] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol,Cumming Sch Med, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Wang, ZB; Tang, CK; Wang, Zongbao] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Med Res Ctr, Hengyang 421001, Peoples R China.

Univ South China, Sch Pharm & Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

apelin-13;PKCα;miR-361-5p;LPL;atherosclerosis

关键词(中文)：

动脉粥样硬化

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2017

卷：

期：

页码：

530-540

DOI：

10.1093/abbs/gmx038

基金类别：

The work was supported by the grants from the National Natural Science Foundation of China (Nos. 81370377, 81570408, and 81300224), Aid Program for Science and Technology Department of Human Province (No. 2015JC3082), the Construct Program of the Key Discipline in Hunan Province, Natural Science Fund of Hunan Province Joint City (No. 13JJ8012), Hunan Provincial Science and Technology Department Research Funding (No. 2014TT2008), Hunan Province Education Department (No. 15C1202), Science and Technology Project of Hunan Province, China (No. 2016DK2001), the University of South China Innovation Foundation for Postgraduate (No. 2016XCX04), and Graduate Student Innovation Project of Cooperative Innovation Center for Molecular Target New Drug (Nos. 0223-0002-D0027 and 0223-0002-D0033).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Atherosclerotic lesions are characterized by the accumulation of abundant lipids and chronic inflammation. Previous researches have indicated that macrophage-derived lipoprotein lipase (LPL) promotes atherosclerosis progression by accelerating lipid accumulation and pro-inflammatory cytokine secretion. Although apelin-13 has been regarded as an atheroprotective factor, it remains unclear whether it can regulate the expression of LPL. The aim of this study was to explore the effects of apelin-13 on the expression of LPL and the underlying mechanism in THP-1 macrophage-derived foam cells. Apelin...

摘要(中文)：

动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素，它是否能调整 LPL 的表示，仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇，免费胆固醇，和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物...

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Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells

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