期刊论文

Cao, Jianguo

英文

生物化学与生物物理学报

1672-9145

2017

49

5

458-464

10.1093/abbs/gmx025

This work was supported by the grants from National Natural Science Foundation of China (No. 30760248 and No. 81172375), the project Scientific Research of Hunan Province the Administration Bureau of Traditional Chinese Medicine (No. 2010081), the Scientific Research of Hunan Province, Department of Education (No. 10C0975), the Major Project Item of Scientific Research of Hunan Province the Department of Education (No. 09A054), the Project of Scientific Research of Changsha City Bureau of Science and Technology (No. K1104060-31), and the Construct Program of the Key Discipline in Hunan Province, China (Basic Medicine Sciences in University of South China).

本校为第一机构

Signal transducer and activator of transcription 3 (STAT3) is a member of the family of latent cytoplasmic transcriptional factors that could regulate cell proliferation, survival, and development. It has been reported that Twist is a target gene of STAT3, and STAT3/Twist signaling plays an important role in regulating cancer progress. Here, to explore whether 8-bromo-7-methoxychrysin (BrMC) inhibits liver cancer stem-like cell (LCSLC) properties via disrupting STAT3/Twist signaling, we cultured SMMC-7721 cells in vitro, and evaluated the effects of BrMC on the stemness of spheroids by determi...

抄写 3 的信号变换器和使活跃之物(STAT3 ) 是能调整房间增长，幸存，和开发的潜伏的细胞质的 transcriptional 因素的家庭的一个成员。扭曲是 STAT3 的目标基因，这被报导了，并且发信号的 STAT3/Twist 在调整癌症进步起一个重要作用。这里，探索 8-bromo-7-methoxychrysin (BrMC ) 是否禁止肝癌症经由破坏 STAT3/Twist 发信号的像茎的房间(LCSLC ) 性质，我们在 vitro 的有教养的 SMMC-7721 房间，并且由决定形成范围的能力和迁居在球状体的 stemness 上评估了 BrMC 的效果。范围形成试金结果在 LCSLC 显示出形成范围的能力的集中依赖者减少(P < 0.05 ) 与 BrMC 的不同集中对待。愈合创伤的试...