期刊论文

Chen, Linxi

英文

生物化学与生物物理学报

1672-9145

2017

49

6

471-478

10.1093/abbs/gmx035

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470434, 81270420]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M560647, 2015T80875]; Hunan Province Cooperative innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document) [2014-405]; Construct Program of the Key Discipline in Hunan Province; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ3102]; Hunan Provincial Science and Technology Project [2015RS4040]; Administration of Traditional Chinese Medicine of Hunan Province [201578]; Health and Family Planning Commission of Hunan Province [B2015-48]

本校为第一且通讯机构

Apelin is the endogenous peptide APJ receptor, while APJ is a member of the G protein-coupled receptors family. Recent evidence strongly suggests that Apelin/APJ system influences apoptosis in various diseases through different signal pathways. In this review, we discuss the possible mechanisms by which the Apelin/APJ system inhibits apoptosis, including the phosphatidylinositol-3-kinase (PI3K)/Akt, ERK1/2, caspase signaling, and autophagy pathway. We also summarize the role of Apelin/APJ system in apoptosis in myocardial ischemia-reperfusion (l/R) injury, pulmonary artery hypertension, retina...

Apelin 是内长的肽 APJ 受体，当 APJ 是 G 联合蛋白质的受体家庭的一个成员时。最近的证据强烈建议那个 Apelin/APJ 系统通过不同信号小径在各种各样的疾病影响 apoptosis。在这评论，我们讨论 Apelin/APJ 系统由禁止 apoptosis 的可能的机制，包括 phosphatidylinositol-3-kinase (PI3K )/Akt， ERK1/2，发信号的 caspase，和 autophagy 小径。我们也在心肌的 ischemia-reperfusion (I/R ) 在 apoptosis 总结 Apelin/APJ 系统的角色损害，肺的动脉高血压，网膜的 neovascular 疾病，尖锐肾的损害，骨胳的动态平衡，和胃肠的疾病。Apelin/APJ 系统减少心肌的梗塞尺寸并且由禁止 cardiomyocytes...