期刊论文

Linxi Chen

英文

生物化学与生物物理学报

1672-9145

2017

49

11

1042-1043

10.1093/abbs/gmx098

This work was supported by the grants from the National Natural Science Foundation of China (No. 81670265), the Natural Science Foundation of Hunan Province (No. 2017JJ2227), and the Cooperative Innovation Center for Molecular Target New Drug Study Undergraduate Innovative Experimental Project in University of South China (0223-0002-00015).

本校为第一且通讯机构

The apelin receptor gene, also known as APJ or angiotensin receptor-like 1, was first cloned in 1993. APJ has strong sequence homology with the angiotensin II receptor (AT1); 54% for intrans membrane domains and 31% for the entire sequence. Nevertheless, APJ does not bind with angiotensin II. In 1998, Apelin, the first endogenous ligand for APJ, was identified in bovine stomach extracts. Both apelin and APJ are widely expressed in various tissues including the heart, brain, limbs, retin...