期刊论文

Li, L.

英文

生物化学与生物物理学报

1672-9145

2017

49

4

378-381

10.1093/abbs/gmx014

This work was supported by the grants from the National Natural Science Foundation of China （Nos. 81470434, 81670265, and 81603108）, Hunan Provincial Science and Technology Project （2015RS4040）, Administration of Traditional Chinese Medicine of Hunan Province （201578）, and Health and Family planning commission of Hunan Province （B2015-48）.

本校为第一且通讯机构

Apelin is an endogenous ligand of the APJ receptor (also known as Aplnr) which is a G protein-coupled receptor. Elabela (also known as Toddler, Apela), which shares little sequence similarity with Apelin (Fig.1),has been identified as a new endogenous ligand for APJ receptor. Elabela is encoded by AK092578 gene from a region of the human genome which was previously classified as 'non-coding'. Elabela is initially translated into a peptide of 54 amino acids including a secretory signal peptide. However, its mature form only contains 32 amino acids. The Elabela/Aplnr axis mainly acts in embryoni...