期刊论文

Li, L.

英文

生物化学与生物物理学报

1672-9145

2016

48

10

966-968

10.1093/abbs/gmw080

This work was supported by the grants from the National Natural Science Foundation of China (81270420 and 81470434) the Construct Program of the Key Discipline in Hunan Province, and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document) (2014-405), the China Postdoctoral Science Foundation (2014M560647 and 2015T80875), Hunan Provincial Science and Technology Project (2015RS4040), Administration of Traditional Chinese Medicine of Hunan Province (201578) and Health and Family Planning Commission of Hunan Province (B2015-48).

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NLRP3 inflammasome is a multi-protein complex that is critical for the activation of caspases-1, maturation, and secretion of proinflammatory cytokines such as interleukin (IL)-1β and IL-18. NLRP3 has three parts: an amino-terminal pyrin domain (PYD), a central nucleotide-binding domain (NBD), and a C-terminal leucinerich repeat (LRR). The interactions among NLRP3, the adapter apoptosis-associated speck-like protein (ASC), and pro-caspase-1 are closely associated with the formation of NLRP3 inflammasome. Under the pathological conditions, the ...