期刊论文

Chen, L.

英文

生物化学与生物物理学报

1672-9145

2016

48

6

589-591

10.1093/abbs/gmw028

This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81270420 and 81470434), the Construct Program of the Key Discipline in Hunan Province, and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document) (No. 2014-405), the China Postdoctoral Science Foundation (Nos. 2014M560647 and 2015T80875), the Hunan Provincial Science and Technology Project (No. 2015RS4040), the Administration of Traditional Chinese Medicine of Hunan Province (No. 201578), and the Health and Family Planning Commission of Hunan Province (No. B2015-48).

本校为第一且通讯机构

APJ, which was initially identified as a gene with closest homology to the angiotensin II type 1 receptor, is a seven transmembrane G protein-coupled receptor. Apelin is an endogenous ligand of the APJ originally isolated from bovine stomach extracts. There are several isoforms of apelin. Apelin preproproteins contain 77 amino-acid residues, which can be cleaved to form shorter bioactive isoforms, including apelin-36, apelin-17, apelin-13, apelin-12, and so on. Apelin/APJ receptor is extensively distributed in the central nervous system and peripheral tissues. Apelin/APJ system involves in a w...

APJ，它是开始与最靠近的相同作为基因识别了到血管收缩素 II 类型 1 受体，是七 transmembrane G 联合蛋白质的受体。Apelin 是原来从牛的胃摘录孤立的 APJ 的内长的 ligand。有 apelin 的几 isoforms。Apelin preproproteins 包含 77 氨基酸的残余，它能被劈开形成更短的 bioactive isoforms 包括 apelin-36， apelin-17， apelin-13， apelin-12 等等。Apelin/APJ 受体广泛地在中央神经系统和外部纸巾被散布。Apelin/APJ 系统在大量生理、病理学的函数包含。例如， apelin 经由 NO/cGMP-dependent 机制降低血压。Apelin-13 在 cardiomyocytes 维持对 ischemia/reperfusion 短暂的 Ca 2+ 。而...