This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81270420 and 81470434), the Hunan Provincial Natural Science Foundation of China (No. 14JJ3102), the Construct Program of the Key Discipline in Hunan Province, and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document) (No. 2014-405), the China Postdoctoral Science Foundation (Nos. 2014M560647 and 2015T80875), the Hunan Provincial Science and Technology Project (No. 2015RS4040), the Administration of Traditional Chinese Medicine of Hunan Province (No. 201578), and Health and Family Planning Commission of Hunan Province (No. B2015-48).