版权说明 操作指南
首页 > 成果 > 详情

A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis: clues for the treatment of other stress-induced diseases

认领
导出
下载 Link by 馆藏
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Di Wu;Lanfang Li;Linxi Chen
通讯作者:
Chen, L.
作者机构:
[Lanfang Li; Di Wu] Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China
[Linxi Chen] Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China lxchen6@126.com
通讯机构:
[Chen, L.] I
Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China
语种:
英文
关键词:
应激性疾病;肿瘤转移;治疗;通道;敏感;癌症患者;转移过程;肿瘤细胞
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2016
卷:
48
期:
5
页码:
487-489
基金类别:
This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81270420 and 81470434), the Hunan Provincial Natural Science Foundation of China (No. 14JJ3102), the Construct Program of the Key Discipline in Hunan Province, and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document) (No. 2014-405), the China Postdoctoral Science Foundation (Nos. 2014M560647 and 2015T80875), the Hunan Provincial Science and Technology Project (No. 2015RS4040), the Administration of Traditional Chinese Medicine of Hunan Province (No. 201578), and Health and Family Planning Commission of Hunan Province (No. B2015-48).
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where most of them die from mechanical deformation. However, cancer cells can survive from mechanical deformation by unknown mechanisms. Recently, Furlow et al. identified a mutation truncated form of pannexin-1 (Panx-1), PANX1~(1–89), which was significant...
摘要(中文):
癌症转移是癌症房间从主要地点和传播背离到另外的区域形成新殖民地的一个过程,它是在癌症病人的死亡的领先的原因。在变形前进期间,传播癌症房间住宿在结束机关的微脉管系统以内,在他们中的大多数从机械变丑死的地方。然而,癌症房间能由未知机制从机械变丑幸存。最近, Furlow 等。[1 ] 鉴别一个变化截断了 pannexin-1 (Panx-1 ) 的形式,显著地在高度变形的癌症房间被充实的 PANX1 1-89, 。PANX1 1-89 扩充 Panx-1 调停隧道的腺苷 triphosphate (ATP ) 版本并且由在物理变丑期间支持变形乳癌房间幸存提高了转移的效率。另外, carbenoxolone (CBX ) ,一个 Panx-1 禁止者,被证明减少乳癌...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com