Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/NF-кB/ZNF202 pathway in THP-1 macrophages

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成果类型：

期刊论文

作者：

Peng, Liangjie;Zhang, Zizhen;Zhang, Min;Yu, Xiaohua;Yao, Feng;...

通讯作者：

Tang, Chaoke;Tian, Guoping

作者机构：

[Gong, Duo; Tang, Chaoke; Chong, Huang; Zhang, Min; Liu, Dan; Yu, Xiaohua; Tan, Yulin; Peng, Liangjie; Yao, Feng; Liu, Xiaoyan] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Ctr,Hunan Prov Cooperat Innovat Ctr Mol T, Hengyang 421001, Peoples R China.

[Peng, Liangjie] XiangNan Univ, Dept Physiol, Chenzhou 423000, Peoples R China.

[Zhang, Zizhen] Hunan Polytech Environm & Biol, Sch Nursing, Hengyang 421001, Peoples R China.

[Zheng, Xilong] Univ Calgary, Hlth Sci Ctr, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta,Cumming Sch Med, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Tian, Guoping] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Peoples R China.

通讯机构：

[Tang, Chaoke; Tian, Guoping] U

Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Ctr,Hunan Prov Cooperat Innovat Ctr Mol T, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

MALP-2;ABCA1;TLR2;NF-κB;ZNF202;cholesterol efflux

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2016

卷：

期：

页码：

363-370

DOI：

10.1093/abbs/gmw013

基金类别：

This work was supported by the grants from the National Natural Science Foundation of China （Nos. 81300224, 81370377, and 81170278）, the Construct Program of the Key Discipline in Hunan Province, and Zhengxiang Scholar Program of University of South China （No. 2014-004）.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Macrophage-activating lipopeptide-2 (MALP-2) has been shown to promote the development of atherosclerosis. ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein, plays a critical role in mediating cholesterol export from macrophages to apolipoprotein A-I (apoA-I). However, whether MALP-2 can regulate the expression of ABCA1 is still largely unknown. The aim of this study was to explore the effects of MALP-2 on ABCA1 expression in THP-1 macrophages and the underlying mechanisms. Our results showed that the treatment of cells with ...

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Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/NF-кB/ZNF202 pathway in THP-1 macrophages

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