Cellular polarization is common to many types of cells, such as vascular endothelial cells (ECs), macrophages, and epithelial cells [1]. An individual cell has opposite sides and the directions of imaginary axes connecting opposite sides are highly coordinated. This coordination of the polarization axes is essential for the function of organs, named planar cell polarity (PCP) [2]. It occurs when cell organelles, cytoskeleton, and/or adhesion complexes display unidirectional organization along an axis. The ECs are continuously exposed to shear stress, and they directly exhibit profound morpholo...