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Receptor-mediated reticulophagy: a novel promising therapy target for diseases

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成果类型:
期刊论文
作者:
Lanfang Li;Jin Xu;Linxi Chen;Zhisheng Jiang
通讯作者:
Chen, L.
作者机构:
Institute of Cardiovascular Disease, University of South China, Key Laboratory for Arteriosclerology of Hunan Province
[Li Lanfang] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
[Li Lanfang; Xu Jin; Chen Linxi] Hunan Province Learning Key Laboratory for Pharmacoproteomics, Hengyang, 421001
Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
Institute of Cardiovascular Disease, University of South China, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang, 421001
通讯机构:
[Chen, L.] H
语种:
英文
关键词:
Receptor-mediated;reticulophagy;diseases
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2016
卷:
48
期:
8
页码:
774-776
基金类别:
This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81270420 and 81470434), the Construct Program of the Key Discipline m Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New' Drug Study (Hunan Provincial Education Department document) (No. 2014-405), the China Postdoctoral Science Foundation (Nos. 2014M560647 and 2015T80875), Hunan Provincial Science and Technology Project (No. 2015RS4040), Administration of Traditional Chinese Medicine of Hunan Province (No. 201578), and Health and Family Planning Commission of Hunan Province (No. B2015-48).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Autophagy is a highly conserved self-digestion process raging from lower eukaryotes to mammals. Autophagy involves in the degradation of misfolded protein aggregates and damaged organelles, which are subsequently reused. Upon autophagy is initiated, a membrane structure termed the phagophore, the precursor of autophagosome, gradually expands and engulfs misfolded protein or damaged organelles and delivers them to the vacuole/lysosome for degradation. Autophagy contributes to the process of survival and death. Basic autophagy is essential for maintaining cellular homeostasis. During normal phys...
摘要(中文):
Autophagy ? 一个高度保存的自我消化过程从更低的优核质正在发怒到哺乳动物。Autophagy 在错误褶层蛋白质总数和损坏细胞器的降级包含,它随后被再使用。在 autophagy 之上被开始,膜结构称为 phagophore, autophagosome 的先锋,逐渐地扩展并且吞没并且为降级把他们送到 vacuole/lysosome 错误褶层蛋白质或损坏细胞器。Autophagy 贡献幸存和死亡的过程。基本 autophagy 为维持细胞的动态平衡是必要的。在正常生理学期间,专业化细胞的功能由清除要求 autophagy 的规定错误褶层蛋白质或损坏细胞器。然而,过多并且 dysregulated autophagy 可以由于从 lysosomes 漏的酶导致 apoptosis 和甚至房...

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