This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81270420 and 81470434), the Construct Program of the Key Discipline m Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New' Drug Study (Hunan Provincial Education Department document) (No. 2014-405), the China Postdoctoral Science Foundation (Nos. 2014M560647 and 2015T80875), Hunan Provincial Science and Technology Project (No. 2015RS4040), Administration of Traditional Chinese Medicine of Hunan Province (No. 201578), and Health and Family Planning Commission of Hunan Province (No. B2015-48).