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H_2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway

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成果类型:
期刊论文
作者:
Gao, Shenglan;Li, Wenting;Zou, Wei;Zhang, Ping;Tian, Ying*;...
通讯作者:
Tian, Ying
作者机构:
[Xiao, Fan; Tang, Xiaoqing; Gao, Shenglan; Gu, Hongfeng] Univ South China, Inst Neurosci, Coll Med, Hengyang 42100, Peoples R China.
[Xiao, Fan; Tang, Xiaoqing; Gao, Shenglan; Gu, Hongfeng] Univ South China, Key Lab Cognit Disorders & Neurodegenerat Dis, Hengyang 421001, Peoples R China.
[Tang, Xiaoqing; Li, Wenting; Zou, Wei; Zhang, Ping] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Peoples R China.
[Tian, Ying] Univ South China, Coll Med, Dept Biochem, Hengyang 421001, Peoples R China.
通讯机构:
[Tian, Ying] U
Univ South China, Coll Med, Dept Biochem, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
brain-derived neurotrophic factor;tyrosine kinase receptor B;corticosterone;hydrogen sulfide;neurotoxicity
关键词(中文):
神经保护作用;PC12细胞;皮质酮;抗毒性;硫化氢;通路;脑源性神经营养因子;调制
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2015
卷:
47
期:
11
页码:
915-924
基金类别:
This work was supported by the grants from the National Natural Science Foundation of China (No. 81371485), the Zhengxiang Scholar Program of University of South China (2014-004), and the Construct Program of the Key Discipline in Hunan Province.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Corticosterone, one of the glucocorticoids, is toxic to neurons and plays an important role in depressive-like behavior and depression. We previously showed that hydrogen sulfide (H2S), a novel physiological mediator, plays an inhibitory role in depression. However, the mechanism underlying H2S-triggered antidepressant-like role is not clearly known. Brain-derived neurotrophic factor (BDNF), a neurotrophic factor, plays a neuroprotective role that is mediated by its high-affinity tropomysin-related kinase B (TrkB) receptor. In this study, to investigate the underlying mechanism of H2S-induced ...

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