期刊论文

Chen, Linxi

英文

生物化学与生物物理学报

1672-9145

2015

47

6

391-396

10.1093/abbs/gmv028

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 81470434, 81470435, 81170277]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ3102]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M560647]; Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]

本校为第一且通讯机构

Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distributed in the circulatory system, while the expressions of Pannexin-2 and Pannexin-3 are mostly restricted to organs and tissues. Pannexin-1 oligomers have been shown to be functional single membrane channels that connect intracellular and extracellular compartments and are not intercellular channels in...

Pannexin-1， Pannexin-2，和 Pannexin-3 是形成隧道的 glycoprotein 的 Pannexin 家庭的三个成员。他们的主要功能是由他们形成单个膜的隧道的能力的 dened。Pannexin-1 无所不在地在整个身体在许多房间和机关存在并且在循环系统是特殊分布式的，当 Pannexin-2 和 Pannexin-3 的表情主要被限制为机关和纸巾时。Pannexin-1 oligomers 被显示了是连接细胞内部、细胞外的分隔空间的功能的单个膜隧道并且不是在同位格的膜的细胞间的隧道。Pannexin-1 的生理的函数是连接到充当一个 paracrine 信号的腺苷 triphosphate 流出，并且在许多房间类型调整细胞的 inflammasomes 在下面生理并且 pathophys...