National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81173035]; National Basic Research Program of ChinaNational Basic Research Program of China [2010CB529802]; National High Technology and Development Program of ChinaNational High Technology Research and Development Program of China [SS2013AA090204]
机构署名：
本校为第一机构
院系归属：
药学与生物科学学院
摘要：
Conotoxins (CTxs) are typically small peptides composed of 12-50 amino acid residues with 2-5 disulfide bridges. Most of them potently and selectively target a wide variety of ion channels and membrane receptors. They are highly valued as neuropharmacological probes and in pharmaceutical development. In this work, a novel α4/6-CTx named ViIA (RDCCSNPPCAHNNPDC-NH2) was identified from a cDNA library of the venom ducts of Conus virgo (C. virgo). ViIA was then synthesized chemically and its disulfide connectivity was identified as 'C1-C3, C2-C4'....
