期刊论文

Jiang, Zhisheng

英文

生物化学与生物物理学报

1672-9145

2015

47

5

362-367

10.1093/abbs/gmv014

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470434, 81270420]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [14JJ3102]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M560647]; Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]

本校为第一且通讯机构

Bone marrow-derived mesenchymal stem cells (BMSCs) are a population of multipotent progenitors that have the capacity of proliferation and differentiation into mesenchymal lineage cells. The regulatory peptide apelin is the endogenous ligand for the G protein-coupled receptor APJ. Apelin, which can enhance BMSC proliferation, has mitogenic effects on a wide variety of cell types. We hypothesized that the increased apelin/APJ might be involved in the occurrence and development of hypoxia-induced BMSC proliferation. BMSCs from the bone marrow of ...

骨头导出髓的间充质的干细胞(BMSC ) 是有增长和区别的能力进间充质的系房间的 multipotent 祖先的一张人口。规章的肽 apelin 是为 G 联合蛋白质的受体 APJ 的内长的 ligand。Apelin，能提高 BMSC 增长，在许多房间类型上有 mitogenic 效果。我们假设了增加的 apelin/APJ 可能涉及导致组织缺氧的 BMSC 增长的出现和发展。从到 10-week-old C57BL/6J 老鼠的 8- 的骨头髓的 BMSC 在 normoxia (21% 氧) 或组织缺氧(1% 氧) 下面是有教养的状况。房间增长被 3-(4,5-dimethylthiazol-2-yl ) 决定 -2,5-diphenyltetrazolium 溴化物试金和 5-bromo-2-deoxyuridine 试金。组织缺氧可诱导的因素(HIF ) 的...