期刊论文

Linxi Chen *

英文

生物化学与生物物理学报

1672-9145

2013

45

10

896-898

10.1093/abbs/gmt090

This work was supported by the grants from the National Natural Science Foundation of China (81270420, 30901577), the Natural Science Foundation of Hunan province joint Hengyang city (12JJ8013), Open Fund of Hunan College Innovation Platform (10K051).

本校为第一且通讯机构

Recently, a paper by Kim et al [1] in Nature Medicine magazine in January, 2013 showed that apelin (also known as APLN) inhibits fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) expression to ameliorate pulmonary hypertension by regulating the expression of miR-424 and miR-503. This study revealed the molecular mechanism of apelin in inhibiting the process of pulmonary arterial hypertension (PAH) and discovered the role of apelin in regulating miRNA generation for the first time. miRNA functions in the transcriptional regulation of gene expression to control cellular processes. miR...