期刊论文

Li, Shuangjie

英文

生物化学与生物物理学报

1672-9145

2013

45

10

817-826

10.1093/abbs/gmt082

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30271665]; Plan Project of Hunan Provincial Science & Technology Department in China [2009JT4010]

本校为第一机构

Doxorubicin (DOX), a widely used anti-tumor drug, can give rise to severe cardiotoxicity by oxidative stress and cell apoptosis, which restricts its clinical application. α-Linolenic acid (ALA) has been shown to serve as a potent cardioprotective agent. The aim of this study was to explore the protective effects of ALA on DOX-induced cardiotoxicity and the underlying molecular mechanisms for this cardioprotection in rats. Rats were randomly divided into four groups and administrated with normal saline, ALA (500 μg/kg), DOX (2.5 μg/kg), or AL...

Doxorubicin (纪录影片) ，广泛地使用的反肿瘤药，能由氧化应力和房间 apoptosis 产生严重 cardiotoxicity，它限制它的临床的申请。亚麻酸的酸(翼) 被显示了用作一个有势力 cardioprotective 代理人。这研究的目的是在老鼠为这 cardioprotection 在导致纪录影片的 cardiotoxicity 和内在的分子的机制上探索翼的保护的效果。老鼠随机被划分成四个组并且与正常管理了盐，翼(500 梭织，任何一个 CheRs 都不能维持上述的互补功能，考虑到类似于 E 的接受甲基的趋化性蛋白质，建议他们的关键角色。coli。由 microarray 试金示威了，在 L 的 cheR1 的表示。在 28 点有教养的 interrogans