期刊论文

Tang, Chaoke

英文

生物化学与生物物理学报

1672-9145

2008

40

3

261-268

10.1111/j.1745-7270.2008.00391.x

This work was supported by the grants from the National Natural Science Foundation of China （30470720）, Post-doctoral Sciences Foundation of China （2005037157）, and Natural Science Foundation of Hunan Province （06jj5058）

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Semicarbazide-sensitive amine oxidase (SSAO) catalyzes oxidative deamination of primary aromatic and aliphatic amines. Increased SSAO activity has been found in atherosclerosis and diabetes mellitus. We hypothesize that the anti-atherogenic effect of liver X receptors (LXRs) might be related to the inhibition of SSAO gene expression and its activity. In this study, we investigated the effect of LXRagonist T0901317 on SSAO gene expression and its activity in apolipoprotein E knockout (apoE−/−) mice. Male apoE−/− mice (8 weeks old) were rando...

Semicarbazide 敏感的胺 oxidase (SSAO ) 催化主要的芳香、脂肪族的胺的氧化 deamination。增加的 SSAO 活动在动脉粥样硬化和糖尿病 mellitus 被发现了。我们假设肝 X 受体(LXR ) 的 anti-atherogenic 效果可能与 SSAO 基因表示和它的活动的抑制有关。在这研究，我们在 apolipoprotein E 大美人在 SSAO 基因表示和它的活动上调查了 LXRagonist T0901317 的效果(apoE /) 老鼠。男 apoE / 老鼠(8 个星期旧) 随机被划分成四个组：基础控制组；车辆组；预防组；并且处理组。SSAO 基因表示被即时量的聚合酶链反应分析，它的活动是坚定的。superoxide dismutase 的活动和在主动脉和肝的 malondialde...