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Adiponectin Decreases Plasma Glucose and Improves Insulin Sensitivity in Diabetic Swine

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成果类型:
期刊论文
作者:
Hu, Xiaobo;She, Meihua;Hou, Hongjie;Li, Qinkai;Shen, Qingyun;...
通讯作者:
Yin, Weidong
作者机构:
[Yin, Weidong; Li, Qinkai; Hu, Xiaobo; Hou, Hongjie; Luo, Yi; She, Meihua; Shen, Qingyun] Nanhua Univ, Dept Biochem & Biotechnol, Sch Life Sci & Technol, Hengyang 421001, Peoples R China.
通讯机构:
[Yin, Weidong] N
Nanhua Univ, Dept Biochem & Biotechnol, Sch Life Sci & Technol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
adiponectin;insulin sensitivity;diabetic swine
关键词(中文):
糖尿病;猪;脂联素;血浆葡萄糖;胰岛素敏感性;降血糖作用
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2007
卷:
39
期:
2
页码:
131-136
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
To investigate the effects of recombinant human adiponectin on the metabolism of diabetic swine induced by feeding a high-fat/high-sucrose diet (HFSD), diabetic animal models were constructed by feeding swine with HFSD for 6 months. The effects of recombinant adiponectin were assessed by detecting the change of plasma glucose levels by commercially available enzymatic method test kits and evaluating the insulin sensitivity by oral glucose tolerance test (OGTT). About 1.5 g purified recombinant adiponectin was produced using a 15-liter fermenter. A single injection of purified recombinant human...
摘要(中文):
To investigate the effects of recombinant human adiponectin on the metabolism of diabeticswine induced by feeding a high-fat/high-sucrose diet (HFSD),diabetic animal models were constructedby feeding swine with HFSD for 6 months.The effects of recombinant adiponectin were assessed bydetecting the change of plasma glucose levels by commercially available enzymatic method test kits andevaluating the insulin sensitivity by oral glucose tolerance test (OGTT). About 1.5 g purified recombinantadiponectin was produced using a 15-liter fermenter.A...

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