Mycotoxin-induced logic gates to execute multichannel intelligent display of DNA biocomputations based on symmetric catalytic hairpin assembly

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成果类型：

期刊论文

作者：

Chen, Junhua*;Wang, Yuyan;Zeng, Ying;Yu, Luxin*;Pan, Jiafeng*

通讯作者：

Chen, Junhua;Yu, Luxin;Pan, Jiafeng

作者机构：

[Chen, Junhua] School of Life and Health Technology, Dongguan University of Technology, Dongguan, 523808, China

[Chen, Junhua] Guangdong Provincial Key Laboratory of Quality & Safety Risk Assessment for Agro-products, Guangzhou, 510640, China. Electronic address: 222chenjunhua@163.com

[Wang, Yuyan; Zeng, Ying] Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China

[Yu, Luxin] Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, the First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, China. Electronic address: yuluxin2006@163.com

[Pan, Jiafeng] Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address: jiafengpan0928@163.com

通讯机构：

[Chen, Junhua; Yu, Luxin] G

[Pan, Jiafeng] H

Guangdong Provincial Key Laboratory of Quality & Safety Risk Assessment for Agro-products, Guangzhou, 510640, China. Electronic address:

Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, the First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, China. Electronic address:

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address:

语种：

英文

关键词：

DNA biocomputation;Fluorescent biosensor;Intelligent sensing;Logic gate;Mycotoxin;Symmetric catalytic hairpin assembly

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2026

卷：

292

页码：

118108

DOI：

10.1016/j.bios.2025.118108

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Despite significant progress has been made in DNA computations, the intelligent display of logic events remains a big challenge. Herein, we reported a logic system for mycotoxin sensing based on symmetric catalytic hairpin assembly (SCHA) using dumbbell DNA as the self-assembly probes. The mycotoxin-aptamer binding releases the trigger DNA, which can launch the SCHA reaction to produce the long-nicked double-stranded DNA products. The obtained fluorescence signals are used to monitor the logic outputs. The numbers “1” and “0” are used to co...

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Mycotoxin-induced logic gates to execute multichannel intelligent display of DNA biocomputations based on symmetric catalytic hairpin assembly

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