Integrated Analysis of RNA-Binding Proteins Associated With the Prognosis and Immunosuppression in Squamous Cell Carcinoma of Head and Neck

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Guangsheng;Jiang, Qingshan;Liu, Lijun;Peng, Hong;Wang, Yaya;...

通讯作者：

Yang, Jing;Liu, Zhifeng

作者机构：

[Hu, Guangsheng; Yang, Jing] Univ South China, Affiliated Hosp 1, Dept Gastroenterol, Hengyang, Peoples R China.

[Peng, Hong; Liu, Zhifeng; Yu, Jing; Jiang, Qingshan; Tang, Yanhua; Li, Shuyan; Liu, Lijun; Wang, Yaya] Univ South China, Affiliated Hosp 1, Dept Otorhinolaryngol, Hengyang, Peoples R China.

[Yang, Jing] Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst, Hengyang, Peoples R China.

通讯机构：

[Yang, Jing; Liu, Zhifeng] U

Univ South China, Affiliated Hosp 1, Dept Gastroenterol, Hengyang, Peoples R China.

Univ South China, Affiliated Hosp 1, Dept Otorhinolaryngol, Hengyang, Peoples R China.

Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst, Hengyang, Peoples R China.

语种：

英文

关键词：

Squamous cell carcinoma of head and neck (SCCHN);RNA binding proteins (RBPs);Differentially Expressed Genes (DEGs);prognosis;tumor immunity

期刊：

Frontiers in Genetics

ISSN：

1664-8021

年：

2021

卷：

页码：

571403

DOI：

10.3389/fgene.2020.571403

基金类别：

This work was supported by grants from the Hunan Provincial Health and Family Planning Commission (20201947 and B20180186), the Hunan Provincial Natural Science Foundation of China (2019JJ50547 and 2018JJ2355), the National Key Research and Development Program of China (2019YFA0802301), and the Hunan Province Science and Technology Department (2017Sk50206).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

RNA-binding proteins (RBPs) interacting with target RNAs play essential roles in RNA metabolism at the post-transcription level. Perturbations of RBPs can accelerate cancer development and cause dysregulation of the immune cell function and activity leading to evade immune destruction of cancer cells. However, few studies have systematically analyzed the potential prognostic value and functions of RBPs in squamous cell carcinoma of head and neck (SCCHN). Here, for the first time, we comprehensively identified 92 differentially expressed RBPs from The Cancer Genome Atlas (TCGA) database. In the...

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Integrated Analysis of RNA-Binding Proteins Associated With the Prognosis and Immunosuppression in Squamous Cell Carcinoma of Head and Neck

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