Antibody-Decorated Nanoplatform to Reprogram Macrophage and Block Immune Checkpoint LSECtin for Effective Cancer Immunotherapy

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成果类型：

期刊论文

作者：

Xu, Rui;Liu, Xiangya;Zhang, Yuxuan;Wu, Guo;Huang, Linzhuo;...

通讯作者：

Li, Rong;Xu, XD

作者机构：

[Li, Rong; Xu, Rui; Xu, Xiaoding; Liu, Xiangya; Li, R; Wu, Guo] Univ South China, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Li, Rong; Xu, Rui; Xu, Xiaoding; Liu, Xiangya; Li, R; Wu, Guo] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Huang, Linzhuo; Xu, Rui; Xu, Xiaoding; Liu, Xiangya; Zhang, Yuxuan; Wu, Guo] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.

[Huang, Linzhuo; Xu, Rui; Xu, Xiaoding; Liu, Xiangya; Zhang, Yuxuan; Wu, Guo] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou Key Lab Med Nanomat, Guangzhou 510120, Peoples R China.

通讯机构：

[Xu, XD ; Li, R] U

Univ South China, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang 421001, Peoples R China.

Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.

Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou Key Lab Med Nanomat, Guangzhou 510120, Peoples R China.

语种：

英文

关键词：

TAMs;repolarization;LSECtin;nanoplatform;cancer immunotherapy

期刊：

NANO LETTERS

ISSN：

1530-6984

年：

2024

卷：

期：

页码：

8723-8731

DOI：

10.1021/acs.nanolett.4c02139

基金类别：

National Natural Science Foundation of China [82173392, 81874226, 81802700]; Guangdong Science and Technology Department [2024B1515040006, 2021A1515111106, 2019A1515011932]; Guangzhou Science and Technology Bureau [20210303004, 202103000093]; Key Research and Development Program of Hunan Province [2021SK2019]; Natural Science Foundation of Hunan Province [2023JJ50149]; The "Three Million for Three Years" Project of the High-level Talent Special Funding Scheme of Sun Yat-Sen Memorial Hospital

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Repolarizing tumor-associated macrophages (TAMs) into tumor-inhibiting M1 macrophages has been considered a promising strategy for enhanced cancer immunotherapy. However, several immunosuppressive ligands (e.g., LSECtin) can still be highly expressed on M1 macrophages, inducing unsatisfactory therapeutic outcomes. We herein developed an antibody-decorated nanoplatform composed of PEGylated iron oxide nanoparticles (IONPs) and LSECtin antibody conjugated onto the surface of IONPs via the hydrazone bond for enhanced cancer immunotherapy. After intravenous administration, the tumor microenvironme...

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Antibody-Decorated Nanoplatform to Reprogram Macrophage and Block Immune Checkpoint LSECtin for Effective Cancer Immunotherapy

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