Chemodynamic therapy (CDT), as an emerging therapeutic strategy, kills cancer cells by converting in-tracellular hydrogen peroxide (H2O2) into cytotoxic oxidizing hydroxyl radicals ( center dot OH). However, the ther-apeutic efficiency of CDT is compromised due to the insufficient endogenous H2O2 and metal catalysts in tumor cells. The use of multivalent polyphenols with multiple hydroxyl functions provides a facile yet robust means for efficient CDT augmentation. For this purpose, we reported herein the construc-tion of polyphenol-metal nanoparticles (NPs) via a phenol-metal coordination stra...
