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Use of recombinant Lactobacillus sakei for the prevention and treatment of radiation-induced enteritis

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成果类型:
期刊论文
作者:
He, Jun-yan;Wang, Wu-zhou;Qi, Hui-zhou;Ma, Yun;He, Shu-ya*
通讯作者:
He, Shu-ya
作者机构:
[He, Shu-ya; Wang, Wu-zhou; He, Jun-yan; Ma, Yun; Qi, Hui-zhou] Univ South China, Med Coll, Hengyang, Peoples R China.
[He, Shu-ya; Wang, Wu-zhou; He, Jun-yan; Ma, Yun] Univ South China, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.
通讯机构:
[He, Shu-ya] U
Univ South China, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
probiotic agent;free radical;probiotic agent;scavenger;antiinflammatory activity;antioxidant activity;Article;enzyme activity;gene;gene expression;genetic transfection;human;ionizing radiation;Lactobacillus sakei;nonhuman;pprI gene;protein expression;radiation enteropathy;radiosensitivity;enteritis;inflammation;intestine mucosa;pathology;radiation injury;radiation protection;vascular endothelium;Endothelium, Vascular;Enteritis;Free Radical Scavengers;Free Radicals;Humans;Inflammation;Intestinal Mucosa;Lactobacillus sakei;Probiotics;Radiation Injuries;Radiation Protection
期刊:
Medical Hypotheses
ISSN:
0306-9877
年:
2018
卷:
119
页码:
37-40
基金类别:
We thank Yong Liu from Mayo Clinic for his linguistic assistance during the preparation of this manuscript. This work is supported by the National Natural Science Foundation of China (Grant No. 81741143), the Education Department of Hunan Province, China (Grant No. 17A186) and the Natural Science Foundation of Hunan Province, China (Grant No. 2018JJ3458). We thank Yong Liu from Mayo Clinic for his linguistic assistance during the preparation of this manuscript. This work is supported by the National Natural Science Foundation of China (Grant No. 81741143 ), the Education Department of Hunan Province , China (Grant No. 17A186 ) and the Natural Science Foundation of Hunan Province , China (Grant No. 2018JJ3458 ).
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
医学院
药学与生物科学学院
摘要:
Radiation-induced enteritis is one of the most common complications in patients under radiotherapy at abdominal or pelvic cavity. Up to 50% of patients treated with pelvic radiotherapy has been reported radiation-induced acute enteritis, and half of them developed chronic enteritis. Overproduction of free radicals, activation of inflammatory pathways and vascular endothelial dysfunction were considered as the primary mechanisms of radiation-induced enteritis. Because probiotics have been demonstrated as a promising potential candidate for treat...

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