Cellular senescence and hematological malignancies: From pathogenesis to therapeutics

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成果类型：

期刊论文

作者：

Hu, Dingyu;Yuan, Shunling;Zhong, Jing;Liu, Zhaoping;Wang, Yanyan;...

通讯作者：

Liu, Jing;Zhang, Ji

作者机构：

[Yuan, Shunling; Liu, Li; Liu, Zhaoping; Wang, Yanyan; Zhang, Ji; Hu, Dingyu] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Ji] Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China.

[Zhong, Jing] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Wen, Feng; Li, Junjun] Univ South China, Affiliated Hosp 1, Dept Hematol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jing] Cent South Univ, Sch Life Sci, Hunan Prov Key Lab Basic & Appl Hematol, Mol Biol Res Ctr, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Jing Liu] H

[Ji Zhang] D

Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China<&wdkj&>Department of Clinical Laboratory, The First Affiliated Hospital, University of South China, Hengyang 421001, Hunan, China<&wdkj&>Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, Hunan, China

语种：

英文

关键词：

Bone marrow (BM) microenvironment;Cellular senescence;Hematological malignancies;Hematopoietic stem cell (HSC);Senescence-associated secretory phenotype (SASP)

期刊：

Pharmacology & Therapeutics

ISSN：

0163-7258

年：

2021

卷：

223

期：

页码：

107817

DOI：

10.1016/j.pharmthera.2021.107817

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870105, 81920108004, 81770107]; Scientific Research Fund Project of Hunan Provincial Health Commission [20201921]; National Key Research and Development Program of China [2018YFA0107800]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ20014]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Cellular senescence constitutes a permanent state of cell cycle arrest in proliferative cells induced by different stresses. The exploration of tumor pathogenesis and therapies has been a research hotspot in recent years. Cellu-lar senescence is a significant mechanism to prevent the proliferation of potential tumor cells, but it can also pro-mote tumor growth. Increasing evidence suggests that cellular senescence is involved in the pathogenesis and development of hematological malignancies, including leukemia, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Cellular senescence is as...

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