期刊论文

Fang, Yimin

英文

Proceedings of the National Academy of Sciences of the United States of America

0027-8424

2018

115

7

E1495-E1503

10.1073/pnas.1717065115

National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AG019899, AG038850, AG031736, AG051869, AR048914, GM089771]; NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) [R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914, R01AR048914] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM089771, R01GM089771, R01GM089771, R01GM089771, R01GM089771, R01GM089771, R01GM089771, R01GM089771, R01GM089771] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01AG031736, P01AG031736, P01AG031736, P01AG031736, P01AG031736, P01AG031736, P01AG031736, R01AG019899, P01AG031736, R21AG051869, P01AG031736, P01AG031736, P01AG031736, R01AG019899, R56AG050531, R01AG019899, P01AG031736, K01AG048264, R01AG019899, K01AG048264, P01AG031736, R01AG019899, P01AG031736, K01AG048264, K01AG048264, P01AG031736, R21AG050225, R01AG019899, P01AG031736, P01AG031736, R21AG038850, P01AG031736, P01AG031736, P01AG031736, P01AG031736, R01AG019899, R01AG019899, P01AG031736, R01AG019899, R21AG051869, P01AG031736, R01AG019899, P01AG031736, P01AG031736, R01AG019899, P01AG031736, P01AG031736, R01AG019899, P01AG031736, R01AG019899, P01AG031736, K01AG048264, P01AG031736, R56AG057734, R21AG051869, P01AG031736, P01AG031736, P01AG031736, P01AG031736, R01AG019899, R01AG019899, R21AG038850, R01AG019899, R01AG019899, R01AG019899, R21AG050225, R01AG019899, P01AG031736, K01AG048264, P01AG031736, R01AG019899] Funding Source: NIH RePORTER

本校为其他机构

It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin (an inhibitor of mTOR) was used in GHR-KO (growth hormone receptor knockout) mice, which have suppressed mTORC1 and up-regulated mTORC2 signaling, to determine the effect of concurrently decreased mTORC1 and mTORC2 signaling on life span. We found that rapamycin extended life span in control normal (N) mice, whereas it had the opposite effect in G...