Identifying vital nodes for yeast network by dynamic network entropy

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成果类型：

期刊论文

作者：

Liu, Jingchen;Wang, Yan;Men, Jiali;Wang, Haohua

通讯作者：

Wang, HH

作者机构：

[Wang, Haohua; Liu, Jingchen] Hainan Univ, Sch Math & Stat, Haikou 570228, Hainan, Peoples R China.

[Wang, Yan] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Men, Jiali] Hainan Univ, Sch Life Sci, Haikou 570228, Hainan, Peoples R China.

[Wang, Haohua; Liu, Jingchen] Hainan Univ, Key Lab Engn Modeling & Stat Computat Hainan Prov, Haikou 570228, Hainan, Peoples R China.

[Liu, Jingchen] Shandong Univ, Sch Math, Jinan 250100, Shandong, Peoples R China.

通讯机构：

[Wang, HH ] H

Hainan Univ, Sch Math & Stat, Haikou 570228, Hainan, Peoples R China.

Hainan Univ, Key Lab Engn Modeling & Stat Computat Hainan Prov, Haikou 570228, Hainan, Peoples R China.

语种：

英文

关键词：

Network entropy;Gene regulatory network;K2 algorithm;Partial least squares;Network simulation;Time series plateau interval

期刊：

BMC Bioinformatics

ISSN：

1471-2105

年：

2024

卷：

期：

页码：

1-15

DOI：

10.1186/s12859-024-05863-x

基金类别：

The work was supported by the National Natural Science Foundation of China (Grant No.12261028, 11961018), the Hainan Province Science and Technology Special Fund (No. ZDYF2021SHFZ231), the Natural Science Foundation of Hainan Province (Grant No. 120RC451, 122QN215), Hainan Province Innovative Scientific Research Project for Graduate Students (Qhys2023-117), Open Project of Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province (HNGCTJ2401), the Specific Research Fund of the Innovation Platform for Academician of Hainan Province.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The progress of the cell cycle of yeast involves the regulatory relationships between genes and the interactions proteins. However, it is still obscure which type of protein plays a decisive role in regulation and how to identify the vital nodes in the regulatory network. To elucidate the sensitive node or gene in the progression of yeast, here, we select 8 crucial regulatory factors from the yeast cell cycle to decipher a specific network and propose a simple mixed K2 algorithm to identify effectively the sensitive nodes and genes in the evolution of yeast. Considering the multivariate of cel...

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Identifying vital nodes for yeast network by dynamic network entropy

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