[Wang, Shiping; Zhu, Cuiming] Cent S Univ, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.
通讯机构：
[Wu, Yimou] U
Univ S China, Pathogen Biol Inst, Dept Microbiol & Immunol, Hengyang 421001, Peoples R China.
语种：
英文
关键词：
Mycoplasma pneumoniae;P1 adhesin protein carboxy terminal region;the B subunit of Escherichia coliheat-labile enterotoxin;DNA vaccine;Mycoplasma pneumoniae;région carboxyterminale de l’adhésine P1;sous-unité B de l’entérotoxine thermolabile d’Escherichia coli;vaccin à ADN
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072418]; Foundation of Education Bureau of Hunan Province, China [09B088]; Innovation Team Foundation of Hunan Province [2010-212]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
In the present study, we investigated the immunomodulatory responses of a DNA vaccine constructed by fusing Mycoplasma pneumoniae P1 protein carboxy terminal region (P1C) with the Escherichia coli heat-labile toxin B subunit (LTB). BALB/c mice were immunized by intranasal inoculation with control DNAs, the P1C DNA vaccine or the LTB-P1C fusion DNA vaccine. Levels of the anti-M. pneumoniae antibodies and levels of interferon-gamma and IL-4 in mice were increased significantly upon inoculation of the LTB-P1C fusion DNA vaccine when compared with the inoculation with P1C DNA vaccine. The LTB-P1C ...
