Static pressure drives proliferation of vascular smooth muscle cells via caveolin-1/ERK1/2 pathway

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, Di-xian*;Cheng, Jiming;Xiong, Yan;Li, Junmo;Xia, Chenglai;...

通讯作者：

Luo, Di-xian

作者机构：

[Liao, Duan-fang; Xia, Chenglai; Luo, Di-xian; Li, Junmo; Wang, Chun; Xu, Canxin; Zhu, Bingyang] Univ S China, Res Ctr Life Sci, Inst Pharm & Pharmacol, Div Pharmacoproteom, Hengyang 421001, Hunan, Peoples R China.

[Hu, Zhuowei] Peking Union Med Coll, Beijing 100730, Peoples R China.

[Hu, Zhuowei] Chinese Acad Med Sci, Inst Mat Med, Beijing 100730, Peoples R China.

[Luo, Di-xian] First Peoples Hosp Chenzhou City, Chenzhou 421001, Hunan, Peoples R China.

[Xiong, Yan; Luo, Di-xian] Cent S Univ, Sch Pharmaceut, Dept Pharmacol, Changsha 410083, Hunan, Peoples R China.

通讯机构：

[Luo, Di-xian] U

Univ S China, Res Ctr Life Sci, Inst Pharm & Pharmacol, Div Pharmacoproteom, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Caveolin-1;Extracellular signal-regulated kinase;Proliferation;Static pressure;Vascular smooth muscle cell

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2010

卷：

391

期：

页码：

1693-1697

DOI：

10.1016/j.bbrc.2009.12.132

基金类别：

National Major Basic Research Program of China (973)National Basic Research Program of China [2006CB503808]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30770868]; Natural Science Foundation of Human Province, ChinaNatural Science Foundation of Hunan Province [06JJ5055]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Intimal hyperplasia plays an important role in various types of vascular remodeling. Mechanical forces derived from blood flow are associated with the proliferation of vascular smooth muscle cells (VSMC). This contributes to many vascular disorders such as hypertension, atherosclerosis and restenosis after percutaneous transluminal angioplasty (PTA). In this study, we show that static pressure induces the proliferation of VSMC and activates its related signal pathway. VSMC from a rat aorta were treated with different pressures (0, 60, 90, 120, ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Static pressure drives proliferation of vascular smooth muscle cells via caveolin-1/ERK1/2 pathway

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问