Trans-urocanic acid facilitates spatial memory, implications for Alzheimer\'s disease - 成果

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Trans-urocanic acid facilitates spatial memory, implications for Alzheimer's disease

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成果类型：

期刊论文

作者：

Yu, Xu-Dong;Li, Ao;Li, Xiao-Ya;Zhou, Yu;Li, Xing;...

通讯作者：

Zhi-Yong Xiao<&wdkj&>Xinhua Shu

作者机构：

[Li, Xing; Li, Ao; Yu, Xu-Dong; Zhou, Yu; He, Zhiming; Wang, Le; Shu, Xinhua] Shaoyang Univ, Sch Basic Med Sci, Shaoyang 422000, Peoples R China.

[Tan, Zhoujin; Li, Xiao-Ya] Hunan Univ Chinese Med, Coll Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Shu, Xinhua; Reilly, James] Glasgow Caledonian Univ, Dept Biol & Biomed Sci, Glasgow City G4 0BA, Scotland.

[Xiao, Zhi-Yong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Crit Care Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhi-Yong Xiao] T

[Xinhua Shu] S

The First Affiliated Hospital,Department of Critical Care Medicine,Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China<&wdkj&>School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China<&wdkj&>Department of Biological and Biomedical Sciences, Glasgow Caledonian University, G4 0BA, Glasgow, United Kingdom

语种：

英文

关键词：

*Alzheimer's disease;*Network pharmacology;*Spatial memory;*Trans-urocanic acid

期刊：

Physiology & Behavior

ISSN：

0031-9384

年：

2022

卷：

252

页码：

113827

DOI：

10.1016/j.physbeh.2022.113827

基金类别：

Department of Education, Hunan Province, China [19C1650]; Hunan Provincial Health Commission, China [20190329, USCKF201902K01]; Lotus Scholarship Program of Hunan Province, China (2019); TENO-VUS Scotland [S20-02]; Chief Scientist Office/the RS Macdonald Charitable Trust [SNRF2021]

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摘要：

Trans-urocanic acid (trans-UCA) is an isomer of cis-UCA and is widely distributed in the brain, predominantly in the hippocampus and prefrontal cortex. Previous studies have investigated the role of trans-UCA in non-spatial memory; however, its influence on spatial memory remains unclear. In the present study, network pharmacology strategy and behavioral testing were used to evaluate the role of trans-UCA in spatial memory and predict its possible mechanism. The results showed that there are 40 intersecting targets between trans-UCA and spatial...

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Trans-urocanic acid facilitates spatial memory, implications for Alzheimer's disease

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