Effect of 2,5-hexanedione on rat ovarian granulosa cell apoptosis involves endoplasmic reticulum stress-dependent m-TOR signaling pathway

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成果类型：

期刊论文

作者：

Zhu, Lemei;Yang, Yue;Tan, Jingsi;Lin, Yibo;Qing, Jiaqi;...

通讯作者：

Li, Xin;Zeng, LF

作者机构：

[Tan, Jingsi; Qing, Jiaqi; Li, Xin; Zhu, Lemei; Zeng, Lingfeng; Lin, Yibo] Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, 1501 Lei Feng St, Changsha 410219, Peoples R China.

[Tan, Jingsi; Qing, Jiaqi; Li, Xin; Zhu, Lemei; Zeng, Lingfeng; Lin, Yibo] Changsha Med Univ, Sch Publ Hlth, 1501 Lei Feng St, Changsha 410219, Peoples R China.

[Yang, Yue] Univ South China, Sch Basic Med Sci, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang Med Sch,Sch Publ Hlth, Hengyang, Peoples R China.

[Zeng, Lingfeng] Hunan Key Lab Pharmacodynam & Safety Evaluat New D, 123 Kangtian Rd, Changsha 410329, Peoples R China.

[Zeng, Lingfeng] Hunan Prov Res Ctr Safety Evaluat Drugs, Changsha, Peoples R China.

通讯机构：

[Li, X; Zeng, LF ] C

Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, 1501 Lei Feng St, Changsha 410219, Peoples R China.

Changsha Med Univ, Sch Publ Hlth, 1501 Lei Feng St, Changsha 410219, Peoples R China.

Hunan Key Lab Pharmacodynam & Safety Evaluat New D, 123 Kangtian Rd, Changsha 410329, Peoples R China.

Hunan Key Lab Pharmacodynam & Safety Evaluat New D, Dept Pharmacol & Toxicol, 123 Kangtian Rd, Changsha 410329, Peoples R China.

语种：

英文

关键词：

2,5-HD;apoptosis;endoplasmic reticulum stress;m-TOR signaling pathway

期刊：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

ISSN：

1528-7394

年：

2025

卷：

期：

页码：

319-328

DOI：

10.1080/15287394.2024.2438832

基金类别：

National Natural Science Foundation of China [82203235]; Hunan Provincial Natural Science Foundation of China [2024JJ6094]; Hunan Provincial Education Commission Foundation [20A056, 22B0898, 23A0664]; Innovation and Entrepreneurship Education Base of Public Health and Preventive Medicine [Hunan Education Bureau] [333-93]; The young backbone teachers of Hunan province training program foundation of Changsha Medical University [Hunan Education Bureau] [29-26, 318-26]; ESI Discipline Special Project of Changsha Medical University [2022CYY010]; National College Students' Innovative Entrepreneurial Training Plan Program [S202410823002, S202310823030]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Occupational exposure to N-hexane/2,5-hexanedione (2,5-HD) was found to adversely affect reproductive functions in females. However, there are few studies regarding the mechanisms underlying reproductive system damage initiated by 2,5-HD. Several studies demonstrated that 2,5-HD exerts hormonal dysfunctions in females by promoting apoptosis using rat ovarian granulosa cells (GCs) as a model. The endoplasmic reticulum (ER) plays a key role in cellular processes such as protein folding and modification, Ca(2+) storage, and lipid synthesis, which ...

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Effect of 2,5-hexanedione on rat ovarian granulosa cell apoptosis involves endoplasmic reticulum stress-dependent m-TOR signaling pathway

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