TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gao, Shan-Shan;Guan, Hua;Yan, Shuang;Hu, Sai;Song, Man;...

通讯作者：

Zhang, Shimeng;Zhou, Ping-Kun

作者机构：

[Zhang, Shimeng; Guan, Hua; Zhou, Ping-Kun; Xie, Fei; Hu, Sai; Liu, Xiaodan; Guo, Zong-Pei; Gao, Shan-Shan; Yan, Shuang; Song, Man] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiat Biol, Beijing 100850, Peoples R China.

[Yan, Shuang] Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang 421001, Hunan, Peoples R China.

[Liu, Yike; Zhou, Ping-Kun] Guangzhou Med Univ, State Key Lab Resp Dis, Inst Chem Carcinogenesis, Guangzhou 511436, Peoples R China.

通讯机构：

[Zhang, SM; Zhou, PK] B

[Zhou, Ping-Kun] G

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiat Biol, Beijing 100850, Peoples R China.

Guangzhou Med Univ, State Key Lab Resp Dis, Inst Chem Carcinogenesis, Guangzhou 511436, Peoples R China.

语种：

英文

期刊：

Science Advances

ISSN：

2375-2548

年：

2020

卷：

期：

DOI：

10.1126/sciadv.aba7822

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81530085, 31870847, 31800704, 81272998]; National Key Basic Research Program (973 Program) of MOST, China [2015CB910601]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Nonhomologous end joining (NHEJ) and homologous recombination (HR) are major repair pathways of DNA double-strand breaks (DSBs). The pathway choice of HR and NHEJ is tightly regulated in cellular response to DNA damage. Here, we demonstrate that the interaction of TIP60 with DNA-PKcs is attenuated specifically in S phase, which facilitates HR pathway activation. SUMO2 modification of TIP60 K430 mediated by PISA4 E3 ligase blocks its interaction with DNA-PKcs, whereas TIP60 K430R mutation recovers its interaction with DNA-PKcs, which results in ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问