期刊论文

中文

中国实验动物学报

1005-4847

2012

20

5

58-61,后插8

10.3969/j.issn.1005-4847.2012.05.013

湖南省科技厅资助项目（编号：2011TT2013） 湖南省研究生科研创新项目（编号：CX2011B382） 衡阳市科技局资助课题（编号：2011ks11）

本校为第一机构

目的 研究腹腔注射硫酸铍( BeSO4·4H2O)对小鼠主要脏器的损害作用.方法 将30只6周龄昆明(KM)雄性小鼠随机分为三组,分别予以不同剂量硫酸铍生理盐水溶液腹腔注射染毒,隔日一次,染毒两周.观察主要脏器的病理组织学变化并测定脏器系数.结果 与对照组比较,染毒组心、脾、肾、睾丸脏器系数无显著差异,肝、肺脏器系数差异有统计学意义(P＜0.05)；对照组肺、肝病理学组织检查未见异常,低剂量组小鼠肺组织可见淤血、出血、支气管扩张出血,肺泡腔内有少量炎性渗出物、支气管周围炎、间质性肺炎、小叶性肺炎等；高剂量组小鼠肺组织可见支气管扩张出血,支气管腔内有大量炎性渗出物,支气管周围肺泡扩张,间...

Objective To observe histopathology changes in the main organs of Kunming（KM） mice after intraperitoneally injection of beryllium sulfate（BeSO4·4H2O）.Methods Thirty 6-week old male KM mice were randomly divided into three groups,administered with saline solution of the beryllium sulfate by intraperitoneally injection every other day for two weeks.The organ coefficients were detected and pathological changes were examined by HE staining.Results Compared with the control group,the organ coefficients of testis,heart,spleen,kidney were not sig...