The Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript-1 Regulates CCDC80 Expression by Targeting miR-141-3p/miR-200a-3p in Vascular Smooth Muscle Cells

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成果类型：

期刊论文

作者：

Gong, Duo;Zhao, Zhen-Wang;Zhang, Qiang;Yu, Xiao-hua;Wang, Gang;...

通讯作者：

Yin, Wei-dong;Tang, Chao-ke

作者机构：

[Gong, Duo; Tang, Chao-ke; Zhao, Zhen-Wang; Yu, Xiao-hua; Yin, Wei-dong; Zhang, Qiang; Wang, Gang; Zou, Jin] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Med Res Expt Ctr, Hengyang, Hunan, Peoples R China.

[Zheng, Xi-long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB, Canada.

[Zheng, Xi-long] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha, Hunan, Peoples R China.

[Zhang, Da-wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

通讯机构：

[Yin, WD; Tang, CK] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MALAT1, miR-141-3p/200a-3p, CCDC80, LPL

期刊：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

ISSN：

0160-2446

年：

2020

卷：

期：

页码：

336-343

DOI：

10.1097/FJC.0000000000000798

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China [81570408, 81773736]; University of South China Innovation Foundation For Postgraduate [2017XCX03]; Molecular Target New Drug Research Collaborative Innovation Center Innovation Project [0223-0002-0002000-41]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

OBJECTIVE: Our previous study showed that Coiled-Coil Domain Containing 80 (CCDC80) accelerates the development of atherosclerosis by decreasing lipoprotein lipase (LPL) expression and activity in apoE knockout mice. However, the regulatory mechanism for CCDC80 expression is unclear. This study was designed to evaluate whether non-coding RNAs involved the regulation of CCDC80 expression in vascular smooth muscle cells (VSMCs). METHODS AND RESULTS: Bioinformatics prediction and luciferase reporter gene results showed that miR-141-3p/200a-3p bound to the 3'UTR of CCDC80. Further, miR-141-3p/200a...

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The Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript-1 Regulates CCDC80 Expression by Targeting miR-141-3p/miR-200a-3p in Vascular Smooth Muscle Cells

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