Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2

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成果类型：

期刊论文

作者：

Zhu, Bo;Sun, Lichun*;Luo, Wei;Li, Min;Coy, David H.;...

通讯作者：

Sun, Lichun

作者机构：

[Yu, Long; Zhu, Bo; Yu, Wenbo; Sun, Lichun] Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Shanghai 200433, Peoples R China.

[Sun, Lichun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New D, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Li, Min; Coy, David H.; Luo, Wei; Sun, Lichun] Cent S Univ, Dept Orthoped, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

[Li, Min; Sun, Lichun] Tulane Hlth Sci Ctr, Dept Med, Sch Med, New Orleans, LA 70112 USA.

[Li, Min] Shanghai Jiao Tong Univ, Dept Radiat Oncol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China.

通讯机构：

[Sun, Lichun] F

[Sun, Lichun] U

[Sun, Lichun] C

[Sun, Lichun] T

Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Shanghai 200433, Peoples R China.

语种：

英文

关键词：

NR4A2;Notch signaling;Notch1;hepatocellular carcinoma;nuclear receptor

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

23289-23302

DOI：

10.18632/oncotarget.15576

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Hepatocellular carcinoma (HCC) is one of the most malignant cancers. Conventional therapies are limited due to the human liver being such a unique organ and easily showing side-effects. The unclear molecular mechanisms are tough challenges for scientists searching for new and effective anti-HCC targeting drugs. We identified that the nuclear receptor NR4A2 is a novel oncogene in HCC progression. In this study, we show that NR4A2 and the notch recceptor Notch1 were expressed highly in primary HCC tissues and immortal HCC cells by using qPCR, western blot and immuno-histochemistry assays. Both g...

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Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2

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