TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Yanmei;Yuan, Chuchu;Qin, Wenhua;Yu, Bo;Wei, Dangheng;...

通讯作者：

Wei, DH;Wu, P

作者机构：

[Chen, Yanmei; Qin, Wenhua; Yu, Bo; Wei, Dangheng; Yuan, Chuchu] Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang 421001, Hunan, Peoples R China.

[Chen, Yanmei] Army Med Univ, Southwest Hosp, Dept Pathol, Chongqing 400038, Peoples R China.

[Wu, Peng] Hengyang Maternal & Child Hlth Hosp, Hengyang 421001, Hunan, Peoples R China.

[Wu, Peng] Hunan Prov Innovat Training Base Med Postgrad, Hunan YueYang Maternal & Child Med Hlth Care Hosp, Yueyang 414000, Hunan, Peoples R China.

通讯机构：

[Wu, P ] H

[Wei, DH ] U

Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang 421001, Hunan, Peoples R China.

Hengyang Maternal & Child Hlth Hosp, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Endothelial cell damage;LPEAT;Mitophagy;Pyroptosis;TMAO

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2024

卷：

703

页码：

149667

DOI：

10.1016/j.bbrc.2024.149667

基金类别：

National Natural Science Foundation of China [82000421]; Natural Science Foundation of Hunan Province [2022JJ40016]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Trimethylamine N-oxide (TMAO) is a novel risk factor for atherosclerosis, and its underlying regulatory mechanisms are under intensive investigation. Inflammation-related vascular endothelial damage is the major driver in atherogenic process. Pyroptosis, a type of proinflammatory programmed cell death, has been proved to promote the initiation and progression of atherosclerosis. In our study, we found that TMAO triggered endothelial cells excessive mitophagy, thereby facilitating pyroptosis. This process is mediated by the upexpression of phosphatidylethanolamine acyltransferase (LPEAT). These...

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TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway

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