Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function

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成果类型：

期刊论文

作者：

Luo, Yan-Hua;Xie, Li;Li, Jiao-Yang;Xie, Yuan;Li, Man -Qin;...

通讯作者：

Li Zhou

作者机构：

[Luo, Yan-Hua; Zhou, Li; Li, Man -Qin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

[Xie, Li] Univ South China, Affiliated Hosp 1, Pediat Med Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Li, Jiao-Yang] Wuhan Univ, Sch Publ Hlth, Dept Prevent Med, Wuhan 430071, Hubei, Peoples R China.

[Xie, Yuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Radiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li Zhou] D

Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of China

语种：

英文

关键词：

children;mitochondrial-derived peptides;MOTS-C;obese;vascular endothelial function

期刊：

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

ISSN：

1178-7007

年：

2024

卷：

页码：

1013-1020

DOI：

10.2147/DMSO.S403934

基金类别：

This work was supported by the Scientific Research Fund key Project of Hunan Provincial Health Commission (No. A2017011) and the Hunan Province Social Science Project (No. XSP22YBC361).

机构署名：

本校为第一机构

摘要：

Purpose: The increasing prevalence of obesity in children and its associated risk with cardiovascular diseases demand more discovery of the novel biomarkers for developing new treatment options for this complex disease. This study aimed to investigate the association of serum MOTS-C (a peptide encoded in the mitochondrial genome) levels and vascular endothelial function in obese children. Patients and Methods: A total of 225 obese children (aged 8.1 ± 2.6 years) and 218 healthy children (aged 7.9 ± 2.2 years) were enrolled. Related anthropome...

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Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function

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