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The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain

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成果类型:
期刊论文
作者:
Wu, Jiajing;Nie, Jianhui;Zhang, Li;Song, Hao;An, Yimeng;...
通讯作者:
Huang, Weijin;Hu, Zhongyu;Wang, Qihui
作者机构:
[An, Yimeng; Wang, Youchun; Liang, Ziteng; Nie, Jianhui; Zhang, Li; Huang, Weijin; Li, Tao; Li, Qianqian; Cui, Zhimin; Wu, Jiajing; Ding, Ruxia; Zhang, Mengyi; Liu, Shuo] Natl Inst Food & Drug Control NIFDC, Inst Biol Prod Control, Div HIV AIDS & Sex Transmitted Virus Vaccines, Beijing 102629, Peoples R China.
[Song, Hao] Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth RNIH, Beijing 100101, Peoples R China.
[Yang, Jing] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, CAS TWAS Ctr Excellence Emerging Infect Dis CEEID, Inst Microbiol,CAS Key Lab Pathogen Microbiol & I, Beijing 100101, Peoples R China.
[Hu, Zhongyu; He, Peng] Natl Inst Food & Drug Control NIFDC, Div Hepatitis & Enter Viral Vaccines, Inst Biol Prod Control, Beijing 102629, Peoples R China.
[Hu, Zhongyu; He, Peng] Minist Hlth Res Qual & Standardizat Biotech Prod, Key Lab, Beijing 102629, Peoples R China.
通讯机构:
[Huang, Weijin; Hu, Zhongyu] N
[Hu, Zhongyu] M
[Wang, Qihui] C
Natl Inst Food & Drug Control NIFDC, Inst Biol Prod Control, Div HIV AIDS & Sex Transmitted Virus Vaccines, Beijing 102629, Peoples R China.
Natl Inst Food & Drug Control NIFDC, Div Hepatitis & Enter Viral Vaccines, Inst Biol Prod Control, Beijing 102629, Peoples R China.
语种:
英文
期刊:
信号转导与靶向治疗
ISSN:
2095-9907
年:
2022
卷:
7
期:
1
页码:
492-501
基金类别:
We sincerely thank the laboratories and associated researchers who obtained the original samples and viral sequence information, as well as those who uploaded and shared genomic data through GISAID. These samples and data were critical to this study and were the cornerstone that allowed this study to proceed smoothly. We thank We thank Acro Biosystems Co. for the recombinant S protein of Alpha, Beta, and Gamma; Dr. Jiankai Liu from Shenzhen Kangtai Biological Products Co., Ltd. and Beijing Minhai Biotechnology Co. for providing inactivated vaccine-immunized sera. We thank Anhui Zhifei Longcom Biopharmaceutical Co., Ltd., and Liaoning Mao Kang Yuan Biotech Co. Ltd. for providing recombinant protein vaccine-immunized sera; Xiaowang Qu of the University of South China for convalescence serum samples. This work was supported by the General Program of the National Natural Science Foundation of China (grant number 82073621 & 82172244), National Key Research and Development Program of China (grant number 2021YFC0863300), Beijing Municipal Science and Technology Project (Z211100002521018), and Bill & Melinda Gates Foundation (Investment ID INV-006379). We thank Gillian Campbell, PhD., from Liwen Bianji (Edanz) (www.liwenbianji.cn), for editing the English text of a draft of this manuscript.
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment. To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine, the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared. The neutralization activities of Alpha, Beta and Gamma variants’ spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations base...

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