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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy

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成果类型:
期刊论文
作者:
Huang, Cui-qin;Xiao, Wen-tao;Yao, Xiang-rong;Li, Zhi-min*;He, Jun-yan
通讯作者:
Li, Zhi-min;He, JY
作者机构:
[Huang, Cui-qin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang, Peoples R China.
[Xiao, Wen-tao] Nantong Univ, Dept Radiat Oncol, Affiliated Hosp, Nantong, Peoples R China.
[Yao, Xiang-rong] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.
[He, Jun-yan; Li, Zhi-min] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.
通讯机构:
[He, JY ; Li, ZM] U
Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
Cervical cancer;POSTN;Prognosis;Radical radiotherapy;Radioresistance
期刊:
Scientific Reports
ISSN:
2045-2322
年:
2025
卷:
15
期:
1
页码:
4174
基金类别:
Natural Science Foundation of Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
医学院
公共卫生学院
摘要:
Cervical cancer (CC) is a significant global health issue and remains one of the leading causes of cancer-related mortality in women. Radiotherapy is a crucial treatment modality for CC; however, tumor heterogeneity and resistance to radiotherapy often result in suboptimal outcomes for some patients, including recurrence and metastasis. Periostin (POSTN), a matricellular protein within the tumor microenvironment, has been implicated in the promotion of tumor progression and treatment resistance, particularly through mechanisms such as epithelial-mesenchymal transition (EMT). Despite this, the ...

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