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LncRNA: An Important Regulator of Atherosclerosis

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成果类型:
期刊论文
作者:
Ma, Yun*;He, Siqi;Xie, Qiao;Tang, Zhihan;Jiang, Zhisheng
通讯作者:
Ma, Yun;Jiang, ZS
作者机构:
[Jiang, ZS; He, Siqi; Tang, Zhihan; Ma, Yun; Jiang, Zhisheng; Xie, Qiao] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.
[Tang, Zhihan; Jiang, Zhisheng; Ma, Yun] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang 421001, Peoples R China.
[Ma, Yun] Univ South China, Hengyang Med Sch, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.
通讯机构:
[Jiang, ZS ; Ma, Y] U
Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
atherosclerosis;biomarker;ceRNA;drug discovery;lncRNAs;prognosis
期刊:
CURRENT MEDICINAL CHEMISTRY
ISSN:
0929-8673
年:
2023
卷:
30
期:
38
页码:
4340-4354
基金类别:
This work was supported by the National Key Research and Development Project (2019YFA0801601) and the National Natural Science Foundation of China (81971087).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Long non-coding RNA (lncRNA) is a kind of biomolecule that can regulate important life activities such as cell proliferation, apoptosis, differentiation, aging, and body development. It has been found that lncRNAs are closely related to various diseases. In cardiovascular diseases, lncRNAs affect the expression level of related genes in atherosclerotic plaques, which are closely related to endothelial dysfunction, smooth muscle cell proliferation, macrophage dysfunction, abnormal lipid metabolism, and cellular autophagy, thus participating in regulating the occurrence and development of AS. In...

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