Oral Chlamydia vaccination induces transmucosal protection in the airway

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成果类型：

期刊论文

作者：

Zhu, Cuiming;Lin, Hui;Tang, Lingli;Chen, Jianlin;Wu, Yimou*;...

通讯作者：

Wu, Yimou;Zhong, Guangming

作者机构：

[Wu, Yimou; Zhu, Cuiming] Univ South China, Inst Pathogen Biol, Dept Med Microbiol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Lingli; Lin, Hui; Chen, Jianlin] Cent S Univ, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China.

[Zhu, Cuiming; Zhong, Guangming; Lin, Hui] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.

通讯机构：

[Wu, Yimou; Zhong, Guangming] U

Univ South China, Inst Pathogen Biol, Dept Med Microbiol, Hengyang 421001, Hunan, Peoples R China.

Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.

语种：

英文

关键词：

*Airway infection;*Chlamydia muridarum;*Oral vaccination;*Transmucosal immunity

期刊：

Vaccine

ISSN：

0264-410X

年：

2018

卷：

期：

页码：

2061-2068

DOI：

10.1016/j.vaccine.2018.03.015

基金类别：

US NIH grantUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01AI121989]; Scholarship Council of China [201308430250]; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI121989, R01AI121989, R01AI121989, R01AI121989] Funding Source: NIH RePORTER

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Although Chlamydia has been frequently detected in the gastrointestinal tracts of both humans and animals, it is not associated with any gastrointestinal pathology. We have recently shown that gastrointestinal Chlamydia muridarum is not only non-pathogenic but also induces protective immunity in the genital tract. We now report that the transmucosal immunity induced by a single oral immunization with C. muridarum protected the mouse airway from a subsequent challenge infection. The oral immunization significantly reduced chlamydial burden in the airway as early as day 3 after intranasal challe...

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Oral Chlamydia vaccination induces transmucosal protection in the airway

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