Recombinant Vascular Basement Membrane Derived Multifunctional Peptide Blocks Endothelial Cell Angiogenesis and Neovascularization

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成果类型：

期刊论文

作者：

Wang, Chengkun;Cao, Jianguo;Qu, Jiaquan;Li, Yafei;Peng, Bo;...

通讯作者：

He, Zhimin

作者机构：

[Peng, Bo; Wang, Chengkun; He, Zhimin; Li, Yafei; Gu, Yixue] Cent S Univ, Canc Res Inst, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.

[Qu, Jiaquan; Wang, Chengkun; Cao, Jianguo] Univ S China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Cao, Jianguo] Hunan Normal Univ, Coll Med, Changsha 410006, Hunan, Peoples R China.

[He, Zhimin] Cent S Univ, Canc Res Inst, Xiangya Sch Med, Xiangya Rd 110, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[He, Zhimin] C

Cent S Univ, Canc Res Inst, Xiangya Sch Med, Xiangya Rd 110, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

RECOMBINANT VASCULAR BASEMENT MEMBRANE DERIVED MULTIFUNCTIONAL PEPTIDE;ANGIOGENESIS INHIBITORS;ENDOTHELIAL CELL;NEOVASCULARIZATION

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2010

卷：

111

期：

页码：

453-460

DOI：

10.1002/jcb.22735

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30472040, 30873088]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Angiogenesis is an innovative target in the therapy of cancer and other diseases, but the effects of anti-angiogenic drugs have been rather modest in clinical trials. We have developed a small peptide, recombinant vascular basement membrane derived multifunctional peptide (rVBMDMP), which significantly inhibits endothelial cells in vitro. Here we test the mechanisms of rVBMDMP in angiogenesis balance in assays of tubule formation, colony formation, and apoptosis in HUVE-12 endothelial cells. We also analyzed the differential expression of phosphorylation proteins and related genes in a protein...

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Recombinant Vascular Basement Membrane Derived Multifunctional Peptide Blocks Endothelial Cell Angiogenesis and Neovascularization

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